منابع مشابه
Contribution of FKBP5 Genetic Variation to Gemcitabine Treatment and Survival in Pancreatic Adenocarcinoma
PURPOSE FKBP51, (FKBP5), is a negative regulator of Akt. Variability in FKBP5 expression level is a major factor contributing to variation in response to chemotherapeutic agents including gemcitabine, a first line treatment for pancreatic cancer. Genetic variation in FKBP5 could influence its function and, ultimately, treatment response of pancreatic cancer. EXPERIMENTAL DESIGN We set out to ...
متن کاملPlacental FKBP5 Genetic and Epigenetic Variation Is Associated with Infant Neurobehavioral Outcomes in the RICHS Cohort
Adverse maternal environments can lead to increased fetal exposure to maternal cortisol, which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol exposure and response, and placental DNA methylation can influence this function. FK506 binding protein (FKBP5) is a negative regulator of cortisol response, FKBP5 methylation has been linked to brain morphology and menta...
متن کاملGenetic Variation within Iranian Iris Species Using Morphological Traits
Iris belongs toIridaceae family and it is monocotyledon. Iris is one of the important ornamental and medicinal plants. 34 iris genotypes (14 species) collected from different provinces of Iran were planted at National Institute of Ornamental Plants (NIOP) Iran. All of the species evaluated for 15 quantitative traits and 30 qualitative traits. Results showed that the highest positive correlation...
متن کاملP-199: Genetic Variation Analysis of MIF in Endometriosis Patients
Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by active macrophages accumulated in ectopic tissue of endometriosis. It involves in pathophysiological events of endometriosis such as angiogenesis, cell proliferation and it can stimulate the synthesis of PGE2 that are necessary for survival and establishment of ectopic endometriosis t...
متن کاملGenetic Variation of Choline Dehydrogenase Gene in Idiopathic Male Infertility
Infertility can be caused by an unexplained reduction in semen quality in males who present asnormal on physical examination and endocrine testing. There is some evidence that aberrantmetabolism of micronutrients such as choline may play a causative role in male factorinfertility. Choline is a crucial factor in the regulation of sperm membrane structure andmotility, and this nutrient plays an i...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2013
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e32835dc133